BICYCLIC DERIVATIVES, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, THEIR USING IN TREATMENT AND METHOD FOR TREATMENT OF MAMMALS BY THEIR USING Russian patent published in 2007 - IPC C07D471/04 A61K31/437 A61P25/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to a compound of the formula (I) involving their pharmaceutically acceptable salts or solvates wherein R means phenyl or pyridinyl, and each of them can be substituted with 1-4 groups chosen from halogen atom, (C₁-C₆)-alkyl, (C₁-C₆)-alkoxy-group, halogen-(C₁-C₆)-alkyl, halogen-(C₁-C₆)-alkoxy-group, nitro-group, -NR₆R₇, cyano-group and R₈ group; R₁ means hydrogen atom or (C₁-C₆)-alkyl; R₂ and R₃ in common with nitrogen atom (N) form group of the formula: ; R₄ means hydrogen atom; R₆ means hydrogen atom or (C₁-C₆)-alkyl; R₇ means hydrogen atom or (C₁-C₆)-alkyl; R₈ represents 5-6-membered saturated or aromatic heterocycle comprising 1-2 heteroatoms chosen independently from nitrogen, oxygen and sulfur atoms. Also, invention describes methods for synthesis of these compounds, pharmaceutical compositions containing these compounds, using in treatment of states mediated by corticotropin-releasing factor, and a method for treatment of mammals using these compounds. Invention provides synthesis of novel compounds possessing valuable biological properties.

EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical composition, improved method of treatment.

22 cl, 1 tbl, 4 ex