CONDENSED N-HETEROCYCLIC COMPOUNDS AND USE THEREOF AS CRF RECEPTOR ANTAGONISTS Russian patent published in 2010 - IPC C07D471/04 C07D487/04 A61K31/437 A61P25/24 

FIELD: chemistry.

SUBSTANCE: described are novel compounds with general formula , their stereoisomers and pharmaceutically acceptable salts or solvates, where the dashed line can represent a double bond (together with the present single bond); R represents phenyl or benzodioxolyl, each of which can be substituted; R₁, R₃ and R₄ independently represent hydrogen or C₁-C₆alkyl; R₅ represents C₁-C₆alkyl; R₇ represents hydrogen; R₁₂ represents R₃ or -C(O)R₂, where R₂ represents C₁-C₄ alkyl; D and G represent -CH₂ - or -CH- when they are bonded to each other by a double bond; m equals 1; a pharmaceutical composition containing said compounds, and use of the novel compounds in treating conditions mediated by corticotropin-releasing factor (CRF).

EFFECT: increased effectiveness of compounds.

11 cl, 13 ex, 11 tbl