DERIVATIVES OF PYRIDOPYRIMIDINES, METHODS FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07D471/04 C07D487/04 A61K31/519 A61P1/00 A61P11/00 A61P19/02 A61P25/28 

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of pyridopyrimidines of the formula (I): or (II): wherein Z means nitrogen atom (N) or -CH; W means -NR²; X¹ means oxygen atom (O), -NR⁴ (wherein R⁴ means hydrogen atom or alkyl), sulfur atom (S) or -CR⁵R⁶ (wherein R⁵ and R⁶ mean hydrogen atom); X² means oxygen atom (O); Ar¹ means unsubstituted or substituted phenyl; R² means hydrogen atom, alkyl or acyl; R¹ means hydrogen atom, alkyl, halide alkyl and others; R³ means alkyl; cycloalkyl and others; R⁸ and R⁹ mean hydrogen atom, alkylsulfonyl and others, and to their pharmaceutically acceptable salts, and to intermediate compounds that are used for preparing compounds of the formula (I) and (II). Indicated compounds show inhibitory activity with respect to activity of p³⁸ kinase and can be used in preparing a medicine agent for treatment of p³⁸-mediated disturbances.

EFFECT: improved preparing methods, valuable medicinal properties of compounds and composition.

38 cl, 3 tbl, 116 ex