FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention describes compounds of the general formula (I) 
wherein radical values are given in the invention claim that are novel histamine receptors antagonist. Preferable compound is 3-[2-[4-(11,12-dihydro-6H-benzimidazo]2,1-b][3]benazepin-6-yl)-2-(phenylmethyl)-1-piperidinyl]ethyl]-2,10-dimethylpyrimido[1,2-α]benzimidazole-4(10H)-one or its salts, isomers and N-oxides. Proposed compounds are useful in prophylaxis and treatment of increased intracranial pressure and/or secondary ischemia caused by craniocerebral trauma.
EFFECT: valuable medicinal properties of compounds, improved method of synthesis.
13 cl, 13 tbl, 5 dwg, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AMINO ACID ESTERS, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING | 1998 |
|
RU2197489C2 |
| TRICYCLIC LACTAM DERIVATIVES AS 11-β-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | 2005 |
|
RU2386617C2 |
| METHOD OF SYNTHESIS OF DERIVATIVES OF N-(3-HYDROXY-4-PIPERIDINYL)-(DIHYDROBENZOFURAN, DIHYDRO-2H-BENZOPYRAN OR DIHYDROBENZODIOXINE)-CARBOXAMIDE, OR THEIR SALTS, OR THEIR STEREOCHEMICALLY ISOMERIC FORM | 1990 |
|
RU2037492C1 |
| CARDIOPROTECTIVE AGENT AND ITS COMPOSITION | 1995 |
|
RU2166319C2 |
| METHOD OF PRODUCING BICYCLIC HETEROCYCLIC N-(BICYCLOHETEROCYCLO)-4-PIPERIDINE DIAMINES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS | 0 |
|
SU1500162A3 |
| IMIDAZOAZEPINE DERIVATIVE, PHARMACEUTICAL COMPOSITION, METHOD OF ITS PREPARING, METHOD OF SYNTHESIS OF IMIDAZOAZEPINE DERIVATIVE | 1994 |
|
RU2133249C1 |
| NEW SUBSTITUTED DIASASPIROPYRIDINE DERIVATIVES APPLIED IN TREATING MCH-1-MEDIATED DISEASES | 2007 |
|
RU2461558C2 |
| PYRIDINE DERIVATIVES USED AS QUICKLY DISSOCIABLE DOPAMINE RECEPTOR 2 ANTAGONISTS | 2008 |
|
RU2480462C2 |
| METHOD OF OBTAINING PENTASACCHARIDE | 0 |
|
SU1694064A3 |
| CONDENSED HETEROCYCLIC SUCCINAMIDE COMPOUNDS | 2001 |
|
RU2298554C2 |
