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2 386 617

(13)

(51)

IPC

C07D209/64(2006-01-01)

C07D209/60(2006-01-01)

C07D471/04(2006-01-01)

C07D495/04(2006-01-01)

A61K31/403(2006-01-01)

A61K31/407(2006-01-01)

A61K31/437(2006-01-01)

A61P3/00(2006-01-01)

(21) (22)

Application

2007111711/04, 2005-08-26

(24)

Start date

2005-08-26

(22)

Actual filing date

2005-08-26

(45)

Published

2010-04-20

(72)

Inventor

Jaroskova LibusheLinders Joannes Teodorus MarijaVan Der Veken Lui Jozef EhlizabetVillemsens Gustaf Khenri Marija

(73)

Holder

Janssen Farmatsevtika N.V.

TRICYCLIC LACTAM DERIVATIVES AS 11-β-HYDROXYSTEROID DEHYDROGENASE INHIBITORS Russian patent published in 2010 - IPC C07D209/64 C07D209/60 C07D471/04 C07D495/04 A61K31/403 A61K31/407 A61K31/437 A61P3/00

Abstract RU 2386617 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula (I), their N-oxide forms, pharmaceutically acceptable additive salts and stereochemically isomeric forms as 11-HSD1 inhibitors, to their use, a pharmaceutical composition based on the said compounds and method of obtaining the said compounds. In general formula (I) , X is C or N; Y is C or N; L is methyl or a single bond; Z¹ is a single bond, C_1-2alkyl or a radical of formula -CH=; Z² is a single bond, C_1-2alkyl; R¹ is hydrogen, halogen, hydroxy; R² is hydrogen, halogen or C_1-4alkyloxy; A is phenyl or a monocyclic heterocycle selected from a group consisting of thiophenyl or pyrridinyl.

EFFECT: obtaining compounds which can be used for treating and preventing diseases mediated by 11-HSD1.

9 cl, 7 dwg, 2 tbl, 34 ex

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RU 2 386 617 C2

Authors

Jaroskova Libushe

Linders Joannes Teodorus Marija

Van Der Veken Lui Jozef Ehlizabet

Villemsens Gustaf Khenri Marija

Dates

2010-04-20—Published

2005-08-26—Filed