FIELD: molecular biology, biochemistry, medicine.
SUBSTANCE: invention proposes double-stranded DNA-oligonucleotides (trap-oligonucleotides) binding transcription factor STAT-1 specifically and neutralizing its effect in cell. Size of trap-oligonucleotides is from 15 to 21 pair nucleotides, and they are characterized by a sequence that comprises 2 sites for binding the STAT-1 protein. Invention shows possibilities in using novel DNA-oligonucleotides as a medicinal agent for prophylaxis and/or therapy of immune hypersensitivity responses.
EFFECT: valuable medicinal properties of oligonucleotides.
3 cl, 14 dwg, 8 ex
