FIELD: medicine; chemistry.
SUBSTANCE: invention relates to oligonucleotide with length from 15 to 30 nucleotides, which is specifically hybridized with natural antisense sequence IRS2 and has sequence, at least by 80 % identical to sequence, which is reverse complementary to section of sequence SEQ ID NO: 3, or has sequence, at least by 80 % identical to section of sequence SEQ ID NO: 1, wherein said oligonucleotide optionally contains one or more modifications, selected from following: at least one modified sugar fragment, at least one modified internucleoside link, at least one modified nucleotide and their combinations.
EFFECT: invention also relates to their application for treating diseases and disorders associated with expression of IRS2.
28 cl, 4 dwg, 2 ex
