IMMUNOCYTOKINES POSSESSING MODULATED SELECTIVITY Russian patent published in 2007 - IPC A61K39/385 C12N15/62 C07K14/55 A61P35/00 

Abstract RU 2312677 C9

FIELD: chemical-pharmaceutical industry, proteins.

SUBSTANCE: invention concerns to cytokine-containing fused proteins showing the enhanced therapeutic index, and methods for enhancing the therapeutic index of these fused proteins. Fused proteins are able for binding with cytokine receptors of more one type expressed on cells and to bind with cells of more one type also. Except for, fused proteins possess a half-time value in blood stream of a patient as compared with that of corresponding natural cytokines.

EFFECT: improved and valuable properties of cytokines.

21 cl, 3 tbl, 11 ex

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RU 2 312 677 C9

Authors

Dzhilliz Stefen D.

Dates

2007-12-20Published

2002-12-04Filed