FIELD: pharmaceuticals; chemistry.
SUBSTANCE: invention relates to chemical-pharmaceutical industry, specifically to a method of producing enterosoluble capsules based on S-ademetionine, involving mixing S-ademetionine of 1,4-butanedisulphonate with copolymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol with molecular weight 90,000-140,000 g/mol at a ratio of 30:70, micronising produced mixture, addition of auxiliary substances, such as microcrystalline cellulose, aerosil and stearic acid and/or calcium or magnesium salt, repeating micronisation and filling gelatin capsules with obtained mixture at following ratio of components, g/capsule: S-ademetionine of 1,4-butanedisulphonate - 0.100; copolymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol with molecular weight 90,000-140,000 g/mol - 0.234; microcrystalline cellulose - 0.221; aerosil - 0.0041; stearic acid and/or calcium or magnesium salt - 0.004.
EFFECT: invention provides higher bioavailability of peroral dosage form of ademetionine and possibility to use low therapeutic doses, its controlled release and high therapeutic effect obtained at same time.
3 cl, 1 ex
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