FIELD: medicine, biology, virology.
SUBSTANCE: invention involves creature of complex of membranotropic compounds providing target delivery of antiviral preparation to HIV-1/2 damaged focus and suppression of viral infection at initial and later steps of its development. Invention provides effect on more expanded targets of human immunodeficiency virus and blocking HIV-infection at the early steps of interaction virus/cell based on synergism of components in the proposed complex. Modifying agents of polyanionic matrix - norbornene or adamantine and peptide-simulators of HIV-1/2 co-receptor bind with different sites of gp120 of HIV-1 that excludes the competition possibility and reciprocal steric hindering in virus-specific pharmacophore-modifying agents. Invention can be used for prophylaxis of HIV-infection and AIDS treatment, and in research works for study of ligand-receptor interaction (of type surface viral proteins - cellular receptors).
EFFECT: valuable biological and medicinal properties of complex.
3 cl, 5 tbl, 2 dwg, 3 ex
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