POLYANIONIC NORBORNAN DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND REPRODUCTION INHIBITORS OF HUMAN IMMUNOGENICITY VIRUS BASED ON THE SAME Russian patent published in 2006 - IPC C08F224/00 C08F122/00 A61K31/341 A61P31/18 

FIELD: polymers, immunology.

SUBSTANCE: invention relates to polyanionic norbornan derivatives of formula I: , wherein or is residue of another oxygen-containing monomer, such as ; n>=15. Preferably n = 35-100 (polymerization ratio); M is H, Na, K, NH₄; X is OH, OM, ONH₃-Y-Nb, NH-Y-Nb, wherein not less 3 % of total X represent sum of ONH₃-Y-Nb and NH-Y-Nb (modification ratio with norbornan), and spacer group -Y- represents - (Y_i)_m [Y_i is CH , CH(CH₃), CH(CH₂CH₃); m>=0, preferably m = 1-3). And norbornan pharmacophor has formula , wherein represents bicyclic norbornan carbon skeleton including seven carbon (C) atoms in 1-7 sites and one (any) substituent from R¹, R^2a, R^2b, R^3a, R^3b, R⁴, R^5a, R^5b, R^6a, R^6b, R^7a, R^7b, represents covalent bond between Nb and Y; and the rest eleven substiruents represent H or alkyl, or two by two represent covalent chemical bond in bicyclic hydrocarbon skeleton, i.e. additional double bond between carbon atoms. Method for production of formula I compounds also is disclosed. Said compounds have high selectivity index in relation to HIV-1 strains, having resistance to known azidotimidine pharmaceutical agent.

EFFECT: polyanionic norbornan derivatives useful as active ingredients of antiviral pharmaceutical formulation.

3 cl, 6 ex, 2 tbl, 4 dwg