METHOD OF PRODUCING 1,4-DIPHENYLAZETIDINONE DERIVATIVES Russian patent published in 2010 - IPC C07D205/08 

FIELD: chemistry.

SUBSTANCE: there is described a method of producing 1,4-diphenylazetidinone derivatives from properly protected β-substituted amino amides in the presence of silylation agents and at least one ring formation catalyst, where 1,4-diphenylazetidinone derivatives have general formula in which symbols, substitutes and indices assume values given in the formula of invention, where this ring formation catalyst is used as a cation in one of the following general formulae

where R¹⁶, R¹⁷, R¹⁸, R¹⁹ independently represent (C₁-C₁₅)alkyl, R⁴¹ represents (C₁-C₁₅) alkyl, R⁴² represents aryl, where the aryl can be substituted with -C(O)NH₂, and as an anion of compounds with formulae or or or and symbols, substitutes and indices assume values given in the formula of invention, where residues from R²⁰ to R³² and from R³⁴ to R³⁸ independently represent H, (C₁-C₆)alkyl, aryl and respectively two alkyl residues together can also form an aryl radical, which can be substituted again with F, O, Br, I, and where R³⁹ and R⁴⁰ together with 1,7,7-trimenylbicyclo[2.2.1]heptanyl, or a cation in that ring formation catalyst corresponds to the cation in general formula (XII), and the anion is R⁴¹O^-, or the cation in that ring formation catalyst corresponds to the cation in general formula (XII), and the anion is R⁴²COO^-, where compounds of general formula in which, unless defined otherwise, symbols, substitutes and indices assume values given in the formula of invention, undergoes ring formation to obtain (pre)products of general formula from which the protection can be removed to obtain formula (I) compounds.

EFFECT: design of a novel method of producing target compounds.

10 cl, 30 ex