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2 276 137

(13)

(51)

IPC

C07D211/26(2006-01-01)

C07D401/12(2006-01-01)

C07D405/12(2006-01-01)

C07H15/26(2006-01-01)

A61K31/706(2006-01-01)

A61K31/445(2006-01-01)

(21) (22)

Application

2003115092/04, 2001-11-21

(24)

Start date

2001-11-21

(22)

Actual filing date

2001-11-21

(45)

Published

2006-05-10

(72)

Inventor

Isikhara TsukasaKhirajama FukusiSugasava KejzoKoga JudziKadokura TakesiSigenaga Takesi

(73)

Holder

Astellas Farma Ink.

SUBSTITUTED DERIVATIVES OF BENZENE OR THEIR SALTS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07D211/26 C07D401/12 C07D405/12 C07H15/26 A61K31/706 A61K31/445

Abstract RU 2276137 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes derivative of benzene or its salt of the formula (I): wherein X¹ means -C(=O)-NR⁵-, -NR⁵-C(=O)-; X²means -NR⁶-C(=O)-, -NR⁶-CH₂-; R¹ means halogen atom, lower alkyl or lower alkoxy-group; R²and R³ mean hydrogen or halogen atom; R⁴ means hydrogen atom, -SO₃H- or sugar residue; ring A represents benzene or pyridine ring; ring B represents piperidine ring, and a pharmaceutical composition based on thereof. Proposed compounds possess anti-coagulating effect based on inhibition of blood coagulation activated factor X that are useful as anti-coagulants or prophylactic agents against diseases caused by thrombosis and embolism.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

5 cl, 9 tbl, 38 ex

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RU 2 276 137 C2

Authors

Isikhara Tsukasa

Khirajama Fukusi

Sugasava Kejzo

Koga Judzi

Kadokura Takesi

Sigenaga Takesi

Dates

2006-05-10—Published

2001-11-21—Filed