METHOD FOR PREPARING INDOLE-3-CARBINOL HYDRATE (VARIANTS) Russian patent published in 2008 - IPC C07D209/12 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to methods (variants) for synthesis of stable form of indole-3-carbonol hydrate. Indole-3-carbonol hydrate is a known compound and used in pharmaceutical industry. Method for synthesis of indole-3-carbinol hydrate involves the reduction reaction of indole-3-carboxaldehyde with sodium boron hydride in (C₁-C₃)-alkyl alcohol medium, Water is added to a prepared reaction mass and kept at decreased temperature up to its complete precipitation followed by drying at environment temperature. Alternative method involves isolation of the reaction product after reaction mass obtained after carrying out the reduction reaction and crystallization from water or aqueous (C₁-C₃)-alkyl alcohol at weak heating, the following cooling and keeping the prepared solution at temperature about zero and its drying at environment temperature. If necessary, synthesized indole-3-carbinol hydrate is re-crystallized additionally from water or aqueous (C₁-C₃)-alkyl alcohol and keeping the prepared solution at temperature from +3°C to -18°C and its drying at environment temperature. Proposed methods provide preparing product showing enhanced stability and without undesirable impurities of by-side conversion substances and solvents used in re-crystallization.

EFFECT: improved method of synthesis.

3 cl, 7 dwg, 7 ex