Show metadata Hide metadata

(19)

(11)

2 470 003

(13)

(51)

IPC

C07C13/62(2006-01-01)

A61P31/12(2006-01-01)

(21) (22)

Application

2011140887/04, 2011-10-07

(24)

Start date

2011-10-07

(22)

Actual filing date

2011-10-07

(45)

Published

2012-12-20

(72)

Inventor

Tolmacheva Irina Anatol'EvnaGrishko Viktorija ViktorovnaIgosheva Ekaterina ViktorovnaBoreko Evgenij IvanovichEremin Vladimir FedorovichKucherov Igor' IvanovichSavinova Ol'Ga Vladimirovna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Tekhnicheskoj Khimii Ural'Skogo Otdelenija Rossijskoj Akademii Nauk Uro Ran)

LUPANE A-SECO-TRITERPENOIDS EXHIBITING ANTIVIRAL ACTIVITY Russian patent published in 2012 - IPC C07C13/62 A61P31/12

Abstract RU 2470003 C1

FIELD: chemistry.

SUBSTANCE: described are lupane A-seco-triterpenoids of general formula: , where R=HCO, R¹=CONHCH₂CH₂COOC₂H₂ or R=HCO, R¹=thiazol-2-yl, R=R¹=CONHCH₂CH₂COOC₂H₅, or R=CH₂OCOCH₃, R¹=COOCH₃ or R=CH₂OCOCH₂CH₂COOH, R¹=COOCH₃ or R=CH₂OCOCH₂C(CH₃)₂COOH, R¹=COOCH₃ or R-CH₂OCOCH₂C(CH₃)₂CH₂COOH, R'=COOCH₃, which exhibit antiviral activity towards herpes simplex virus I (HSV-1, strain 1 C). Compounds with R-R¹=CONHCH₂CH₂COOC₂H₅ combine antiviral activity towards herpes virus with anti-HIV activity.

EFFECT: compounds have potential in producing antiviral agents and as key intermediates in producing novel biologically active compounds.

3 cl, 9 ex, 2 tbl

Similar patents RU2470003C1

Title	Year	Author	Number
TRITERPENOIDS WITH EH-NITRILE FRAGMENT IN A-PENTACYCLE	2012	Grishko Viktorija Viktorovna Tolmacheva Irina Anatol'Evna Galajko Natal'Ja Vladimirovna Boreko Evgenij Ivanovich Eremin Vladimir Fedorovich Savinova Ol'Ga Vladimirovna Kucherov Igor' Ivanovich	RU2496785C1
3-HYDROXIMINO DERIVATIVES OF 2,3-SECOLUPANE TYPE, DEMONSTRATING INHIBITING ACTIVITY WITH RESPECT TO INFLUENZA A AND HIV-1 VIRUS	2011	Grishko Viktorija Viktorovna Tolmacheva Irina Anatol'Evna Galajko Natal'Ja Vladimirovna Boreko Evgenij Ivanovich Eremin Vladimir Fedorovich Savinova Ol'Ga Vladimirovna Kucherov Igor' Ivanovich	RU2475476C1
A-SECO-TRITERPENOIDS WITH METHYLKETONE FRAGMENT	2013	Tolmacheva Irina Anatol'Evna Grishko Viktorija Viktorovna Pereslavtseva Anastasija Vladimirovna Eremin Vladimir Fedorovich Boreko Evgenij Ivanovich Kucherov Igor' Ivanovich Savinova Ol'Ga Vladimirovna	RU2537840C1
TRITERPENE LUPANE-TYPE AMIDES WITH FRAGMENT OF 2-AMINOBUTAN-1-OL EXHIBITING VIRUS-INHIBITING AND VIRUCIDAL ACTIVITY	2017	Igosheva Ekaterina Viktorovna Eremin Vladimir Fedorovich Boreko Evgenij Ivanovich Savinova Olga Vladimirovna Tolmacheva Irina Anatolevna Grishko Viktoriya Viktorovna	RU2664804C1
2,3-SECO-DERIVATIVES OF BETULONIC ACID	2009	Tolmacheva Irina Anatol'Evna Grishko Viktorija Viktorovna Boreko Evgenij Ivanovich Savinova Ol'Ga Vladimirovna Pavlova Natal'Ja Il'Inichna	RU2410390C1
CYTOTOXIC AND ANTI-VIRAL ACTIVITY OF 3-ACYLOXIMETHYL-3-OXO-1-CYANO-2,3-SECO-2-NOR-TRITERPENOIDES	2018	Krajnova Gulnaz Faizovna Savinova Olga Vladimirovna Eroshenko Darya Vladimirovna Boreko Evgenij Ivanovich Eremin Vladimir Fedorovich Grishko Viktoriya Viktorovna	RU2682669C1
CYTOTOXIC AND ANTIVIRAL ACTIVITY OF 3-ACYLOXYMETHYL-3-OXO-1-CYANO-2,3-SECO-2-NOR-TRITERPENOIDS	2018	Krajnova Gulnaz Faizovna Eroshenko Darya Vladimirovna Grishko Viktoriya Viktorovna	RU2686100C1
HIV-1 AND INFLUENZA A VIRUS REPRODUCTION INHIBITOR	2012	Boreko Evgenij Ivanovich Eremin Vladimir Fedorovich Grishko Viktorija Viktorovna Tolmacheva Irina Anatol'Evna	RU2477134C1
NUCLEOSIDE ESTERS AND PHARMACEUTICAL COMPOSITION	1992	Are Dalen Finn Mjukhren Bernt Berretsen K'Ell' Turgejr Stukke	RU2126417C1
SUBSTITUTED SPIRO ANDROSTENES-17, 6'[1,3,4]THIADIAZINES WITH ANTIVIRAL ACTIVITY	2021	Malykh Andrej Gennadevich Pavlov Andrej Removich Volkova Yuliya Alekseevna Komkov Aleksandr Vladimirovich Menchikov Leonid Gennadevich Zavarzin Igor Viktorovich	RU2750639C1

RU 2 470 003 C1

Authors

Tolmacheva Irina Anatol'Evna

Grishko Viktorija Viktorovna

Igosheva Ekaterina Viktorovna

Boreko Evgenij Ivanovich

Eremin Vladimir Fedorovich

Kucherov Igor' Ivanovich

Savinova Ol'Ga Vladimirovna

Dates

2012-12-20—Published

2011-10-07—Filed