TETRAZOLE DERIVATIVE-CONTAINING OPHTHALMIC SOLUTIONS Russian patent published in 2008 - IPC A61K9/08 A61K31/41 A61P27/02 

Abstract RU 2318493 C2

FIELD: organic chemistry, medicine, ophthalmology.

SUBSTANCE: invention relates to an ophthalmic solution containing compound of the following chemical formula (I): wherein R1 represents group of the formula (Ia): or its pharmaceutically acceptable salt or derivative, cationic antiseptic agent and basic amino-compound wherein cationic antiseptic agent represents quaternary ammonium salt or chlorhexidine, and basic amino-compound represents at least one compound chosen from trometamol, lidocaine and nicotinamide. Quaternary ammonium salt represents benzalconium chloride, benzetonium chloride, cetylpyridinium or cetrimide. Ophthalmic solution can contain additionally boric acids, ethylenediaminetetraacetic acids. Owing the presence of additives the invention provides enhancing antiseptic effect of ophthalmic solutions.

EFFECT: improved and valuable medicinal properties of ophthalmic solutions.

11 cl, 4 tbl, 2 dwg, 7 ex

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RU 2 318 493 C2

Authors

Uneda Takesi

Kimura Akio

Morisima Kendzi

Dates

2008-03-10Published

2003-03-10Filed