METHOD FOR EXPERIMENTAL BIOTHERAPY OF B16/F10 MELANOMA Russian patent published in 2022 - IPC G09B23/28 A61K35/407 A61P35/00 

Abstract RU 2779698 C1

FIELD: oncology.

SUBSTANCE: invention relates to oncology, namely to experimental oncology, and can be used to study the antitumor effect on melanoma in the experiment. To do this, female and male BALB/c Nude mice are injected subcutaneously under the scapula on the left with a suspension of B16/F10 murine melanoma tumor cells in 0.5 ml of saline at a dilution of 1:20. 24 hours after inoculation of B16/F10 melanoma, mice are intraperitoneally injected with freshly isolated mitochondria from rat liver at the rate of 3.3 mg of protein per 1 animal in 0.3 ml of saline. Further, mitochondrial therapy is carried out according to the scheme for 3, 5, 9, 13, 16, 19, 21 days.

EFFECT: invention makes it possible to slow down tumor growth in mice of both sexes, to study the pathogenesis of malignant growth under the influence of the introduction of a mitochondrial suspension and the mechanism of mitochondrial action.

1 cl, 1 tbl, 3 dwg

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RU 2 779 698 C1

Authors

Frantsiiants Elena Mikhailovna

Shikhliarova Alla Ivanovna

Neskubina Irina Valerevna

Kaplieva Irina Viktorovna

Surikova Ekaterina Igorevna

Bandovkina Valeriia Akhtiamovna

Trepitaki Lidiia Konstantinovna

Pogorelova Iuliia Aleksandrovna

Cheriarina Natalia Dmitrievna

Ishonina Oksana Georgievna

Dates

2022-09-12Published

2022-02-10Filed