FIELD: oncology.
SUBSTANCE: invention relates to oncology, namely to experimental oncology, and can be used to study the antitumor effect on melanoma in the experiment. To do this, female and male BALB/c Nude mice are injected subcutaneously under the scapula on the left with a suspension of B16/F10 murine melanoma tumor cells in 0.5 ml of saline at a dilution of 1:20. 24 hours after inoculation of B16/F10 melanoma, mice are intraperitoneally injected with freshly isolated mitochondria from rat liver at the rate of 3.3 mg of protein per 1 animal in 0.3 ml of saline. Further, mitochondrial therapy is carried out according to the scheme for 3, 5, 9, 13, 16, 19, 21 days.
EFFECT: invention makes it possible to slow down tumor growth in mice of both sexes, to study the pathogenesis of malignant growth under the influence of the introduction of a mitochondrial suspension and the mechanism of mitochondrial action.
1 cl, 1 tbl, 3 dwg
| Title | Year | Author | Number |
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| A METHOD FOR MODELING THE PRIMARY MULTIPLE GROWTH OF MALIGNANT TUMORS WITH THE SUPPRESSION OF ONE TUMOR BY ANOTHER IN THE CONDITIONS OF PRIMARY IMMUNODEFICIENCY | 2021 |
|
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| METHOD FOR ENHANCING THE GROWTH OF B16/F10 MELANOMA VERSUS THE GROWTH OF B16/F10 MELANOMA WITH SELF-GRAFTING AND SLOWING THE GROWTH OF LLC (LEWIS CARCINOMA) VERSUS THE GROWTH OF LLC WITH SELF-GRAFTING IN CASE OF MULTIPLE PRIMARY MALIGNANT TUMORS AGAINST THE BACKGROUND OF PRIMARY IMMUNODEFICIENCY | 2021 |
|
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| METHOD FOR CREATING POLYNEOPLASIA WITH STIMULATION OF TUMOR GROWTH IN CONDITIONS OF PRIMARY IMMUNODEFICIENCY IN EXPERIMENT | 2021 |
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| METHOD FOR DETECTING PROPERTIES OF HUMAN GLIOBLASTOMA MITOCHONDRIA TO INDUCE EXTRACRANIAL DIFFUSE TUMOR GROWTH IN THE ORGANS OF EXPERIMENTAL ANIMALS | 2023 |
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| METHOD FOR REVERSING GENETICALLY DETERMINED INHIBITION OF GROWTH OF A MALIGNANT TUMOR IN EXPERIMENT | 2019 |
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