METHOD FOR APPLYING PHOTODYNAMIC CHOROIDEA MELANOMA THERAPY Russian patent published in 2008 - IPC A61K31/409 A61P27/02 A61P35/00 A61N5/67 

FIELD: medicine.

SUBSTANCE: method involves intravenously introducing chlorine row photosensitizer at a dose of 0.8-1.0 mg/kg, 70% of the dose being drop-by-drop infused during 10 min. The remaining 30% are introduced as bolus dose 1.5 h later. Photosensitizer introduction being finished, the neoplasm is transpupillarily exposed to laser radiation at wavelength corresponding to photosensitizer light absorption maximum with some overlap of neighboring fields. Tumor periphery is irradiated with intact tissue being caught not less than 1 mm far from ophthalmoscopically visible tumor boundary at power density of 25-40 J/cm². Then, the whole tumor surface is concentrically irradiated from periphery to the center by applying power density of 110-120 J/cm². 2 weeks later, photosensitizer intravenous injection is repeated and transpupillary laser radiation treatment of tumor surface. 2-4 intravenous photosensitizer injection sessions and tumor surface irradiation are given to achieve its complete resorption.

EFFECT: minimized adjacent intact tissue exposure; excluded recurrence and tumor dissemination in remote postoperative period.

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