METHOD FOR PREDICTING CLINICAL COURSE OF RESPIRATORY ORGANS SARCOIDOSIS ON THE BACKGROUND OF GLUCOCORTICOID THERAPY Russian patent published in 2008 - IPC A61B10/00 G01N33/86 

FIELD: medicine.

SUBSTANCE: method involves determining the following hemostasis parameters before beginning, in a month and one year later after 0 mg/kg during 10 min after glucocorticoid therapy when indications to applying steroid therapy are available. The parameters are procoagulant activity as activated partial thromboplastin time, s, prothrombin index; anticoagulant activity as antithrombine III, %, protein-C as well as fibrinogen, g/l and fibrinolytic blood activity, min and their changes on the background of additional respiratory resistance action 40% Pm_max during 3 min. If procoagulant activity as response to additional respiratory resistance falls before and during the treatment with prothrombin index decreasing and activated partial thromboplastin time growing, anticoagulant activity as antithrombine III, protein-C grows whereas fibrinogen and fibrinolytic blood activity remain unchanged especially towards the year end, favorable clinical course of sarcoidosis is to be predicted. If procoagulant activity as response to additional respiratory resistance grows before and in a month after the glucocorticoid therapy with prothrombin index growing and activated partial thromboplastin time decreasing, one year later their activity falling, anticoagulant activity as antithrombine III, protein-C grows as well as fibrinogen and fibrinolytic blood activity remain unchanged during the whole investigation time, disease regress retardation and high probability of fibrous changes being occurred in lungs is to be predicted.

EFFECT: high accuracy of prognosis.