METHOD OF DIFFERENTIAL DIAGNOSTICS OF HEMOSTASIS DISPRDERS IN LEPTOSPIROSIS Russian patent published in 2018 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to infectious diseases, and can be used for differential diagnosis of hemostasis disorders in leptospirosis. Method includes determining after detection of clinical signs of leptospirosis the number of platelets (Pl), prothrombin index (PTI), the content of fibrinogen, activated partial thromboplastin time (APTT), platelet aggregation area (Spa), ristomycin-cofactor activity of von Willebrand factor (WF), level of soluble fibrin monomer complexes (SFMC). Then, based on the specified parameters: x₁ – Pl; x₂ – PTI; x₃ – Fibrinogen; x₄ – APTT; x₅ – Spa; x₆ – WF; x₇ – SFMC by formulas, determine the variants of hemostasis disorders, (G): G₁=-164.757+21.366x₁+61.182x₂+1.615x₃+52.351x₄+38.425x₅+121.727x₆+3.788x₇; G₂=-165.085+10.751x₁+65.915x₂-1.212x₃+51.486x₄+53.008x₅+105.692x₆+0.728x₇; G₃=-139.836+56.347x₁+77.306x₂-0.959x₃+47.539x₄+27.875x₅+96.970x₆+0.669x₇; G₄=-123.808+50.170x₁+49.304x₂-1.889x₃+52.638x₄+29.901x₅+95.247x₆+1.845x₇; G₅=-186.544+35.336x₁+68.731x₂-1.355x₃+48.172x₄+25.020x₅+146.688x₆+1.605x₇, where among the values of G₁, … G₅ select G with the highest value corresponding to the variant of hemostasis disorder: G₁ – corresponds to a syndrome of disseminated intravascular blood coagulation (DIC-syndrome); G₂ – isolated thrombocytopenia (IT), G₃ – absence of coagulopathy, G₄ – a hepatic variant of coagulopathy, G₅ – uremic variant of hemostasis disturbance.

EFFECT: use of the invention makes it possible to shorten the time for interpreting laboratory studies, individualize further therapeutic tactics.

1 cl, 4 tbl, 4 ex