METHOD FOR PREDICTION OF GLUCOCORTICOSTEROID CLINICAL EFFECTIVENESS Russian patent published in 2010 - IPC G01N33/49 

Abstract RU 2382364 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine and can be used in laboratory study to find the indications for the glucocorticoid therapy. It is ensured by examination in vitro of monocytes of peripheral blood wherefore monocytes are activated within 10-20 minutes with a helium-neon laser of power (0.5-1.0) Wt/cm2. As morphometric parametres of monocytes, an optical thickness of monocyte nuclei is recorded. Then monocytes are exposed to prednisolone, and the optical thickness of monocyte nuclei is recorded once more. The increased indicator by 30% and more enables to predict glucocorticosteroid clinical effectiveness.

EFFECT: application of the offered study method prior to glucocorticosteroid therapy allows avoiding unreasonable prescription of said preparations, since even short-term application can lead to various complications.

2 ex

Similar patents RU2382364C1

Title Year Author Number
METHOD FOR ASSESSING THE FUNCTIONAL STATE OF PERIPHERAL BLOOD LYMPHOCYTES 2021
  • Dmitriev Anatolij Fedorovich
  • Agarkov Aleksandr Viktorovich
  • Agarkov Nikolaj Viktorovich
RU2763845C1
METHOD FOR PREDICTING CLINICAL COURSE OF SARCOIDOSIS 2013
  • Terpigorev Stanislav Anatol'Evich
  • Korsakova Nina Anatol'Evna
  • Gurevich Larisa Evseevna
  • Il'Chenko Vladimir Aleksandrovich
RU2549454C1
METHOD FOR DETERMINING DEGREE OF T-LYMPHOCYTE ENERGISING 2014
  • Kretushev Aleksandr Viktorovich
  • Klemjashov Ivan Valerievich
  • Vyshenskaja Tatjana Vladimirovna
  • Evdokimov Anatolij Arkadievich
RU2577118C1
METHOD FOR ASSESSING FUNCTIONAL STATE OF HUMAN LYMPHOCYTE 2013
  • Tychinskij Vladimir Pavlovich
  • Kretushev Aleksandr Viktorovich
  • Vyshenskaja Tat'Jana Vladimirovna
RU2543340C2
METHOD OF in vitro ESTIMATING INDIVIDUAL REACTION OF PATIENT'S ORGANISM TO ACTION OF PHARMACOLOGICAL PREPARATION 2012
  • Tychinskij Vladimir Pavlovich
  • Kretushev Aleksandr Viktorovich
  • Vyshenskaja Tat'Jana Vladimirovna
  • Klemjashov Ivan Valerievich
RU2526134C2
METHOD FOR PREDICTION OF PATIENT'S IMMUNE RESPONSE TO ENVIRONMENTAL EXPOSURE 2012
  • Tychinskij Vladimir Pavlovich
  • Kretushev Aleksandr Viktorovich
  • Vyshenskaja Tat'Jana Vladimirovna
RU2543336C2
METHOD FOR PYOINFLAMMATORY COMPLICATIONS PREDICTION IN MAXILLOFACIAL TRAUMA CASES 2007
  • Nikitin Aleksandr Aleksandrovich
  • Vasilenko Irina Anatol'Evna
  • Malychenko Nelli Vsevolodovna
  • Metelin Vladislav Borisovich
  • Ivanjuta Irina Vladimirovna
RU2331879C1
METHOD OF ASSESSING INFLAMMATORY PROCESS ACTIVITY IN SARCOIDOSIS 2010
  • Vereshchagina Viktorija Mikhajlovna
  • Terpigorev Stanislav Anatol'Evich
  • Sukolina Ol'Ga Gennadievna
RU2423701C1
METHOD OF INDIVIDUAL RECOVERY OF FUNCTIONAL ACTIVITY OF ADRENAL CORTEX IN PATIENTS WITH SOMATIC DISEASES WITH LONG HISTORY OF GLUCOCORTICOSTEROID THERAPY 2010
  • Tishenina Raisa Stepanovna
  • Stotskaja Tat'Jana Vasil'Evna
  • Molochkov Vladimir Alekseevich
  • Jankovskaja Nina Igorevna
  • Borodina Elena Georgievna
RU2439563C1
METHOD FOR PREDICTING CLINICAL COURSE OF MULTIPLE ORGAN FAILURE IN EXTRACORPORAL THERAPY 2008
  • Fomin Aleksandr Mikhajlovich
  • Vasilenko Irina Anatol'Evna
  • Koshelev Ruslan Viktorovich
  • Metelin Vladislav Borisovich
  • Volgina Julija Dmitrievna
RU2377566C1

RU 2 382 364 C1

Authors

Vasilenko Irina Anatol'Evna

Paleev Nikolaj Romanovich

Tychinskij Vladimir Pavlovich

Vyshenskaja Tat'Jana Vladimirovna

Kretushev Aleksandr Viktorovich

Terpigorev Stanislav Anatol'Evich

Kastrikina Irina Sergeevna

Ehl'Zejn Bilal Amine

Dates

2010-02-20Published

2008-12-26Filed