1-HYDROXYADAMANTANON-4-ONE PREPARATION METHOD Russian patent published in 2008 - IPC C07C49/513 C07C45/28 

FIELD: organic synthesis and pharmaceutical industry.

SUBSTANCE: invention provides a method for preparation of 1-hydroxyadamantanon-4-one (Kemantan), which can be used as immunostimulating drug effective to treat vascular system diseases, limbs autoimmune genesis extremities, tuberculosis, infection-allergic bronchial asthma, chronic aphthous stomatitis, herpes, as well as anticataleptic agent and intermediate for synthesis of 1,4-bifunctional derivatives of adamantane. Method comprises oxidation of adamantanone by means of sulfuric/nitric acid mixture in the form of complex oxidation-activating system including sulfuric, nitric, and acetic acids, molar ratio adamantanone/sulfuric acid/nitric acid/acetic acid being 1: (1.75) : (8.43-12.62) : (0.25-1). Process is carried out when stepwise raising temperature: first, at 35°C, nitric acid is measured out to reaction mass for 1-1.5 h, after which temperature is raised to 50-55°C for 12-16 h.

EFFECT: increased yield of 1-hydroxyadamantanon-4-one and improved its purity.

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