FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 1-hydroxy-4-adamantanone - the active ingredient of immunomodulating drug Kemantan. The method includes oxidising adamantane with 98% sulphuric acid at 70-82°C for 9-15 hours and further reaction with fuming nitric acid, followed by heating the reaction mixture for 6 hours at 25-45°C.
EFFECT: method enables to obtain the end product using simple and safe technology.
10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING HYDROCHLORIDES OF ADAMANTANE AMINES | 2013 |
|
RU2541545C2 |
| METHOD OF SYNTHESIS OF 1-HYDROXYADAMANTANE-4-ONE (MEDICINAL AGENT "KEMANTAN") | 1994 |
|
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| METHOD OF PRODUCING 1-HYDROXYADAMANTAN-4-ONE | 2011 |
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|
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| METHOD OF PRODUCING TRIBASIC CARBOXYLIC ACIDS OF ADAMANTANE SERIES | 2014 |
|
RU2569376C1 |
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| METHOD FOR PREPARING 1-ARYL-4-OXOADAMANTANES | 2005 |
|
RU2295512C1 |
