Show metadata Hide metadata

(19)

(11)

2 319 745

(13)

(51)

IPC

C12P21/02(2006-01-01)

C07K14/435(2006-01-01)

(21) (22)

Application

2006131826/13, 2006-09-06

(24)

Start date

2006-09-06

(22)

Actual filing date

2006-09-06

(45)

Published

2008-03-20

(72)

Inventor

Kozlov Sergej AleksandrovichVasilevskij Aleksandr AleksandrovichSamsonova Ol'Ga VjacheslavovnaPoljanskij Anton AleksandrovichVolynskij Pavel Evgen'EvichFeofanov Aleksej Valer'EvichEfremov Roman GerbertovichArsen'Ev Aleksandr SergeevichGrishin Evgenij Vasil'Evich

(73)

Holder

Institut Bioorganicheskoj Khimii Im. Akademikov M.M. Shemjakina I Ju.A. Ovchinnikova Rossijskoj Akademii Nauk

PEPTIDE LATARCIN ELICITING ANTIBACTERIAL ACTIVITY Russian patent published in 2008 - IPC C12P21/02 C07K14/435

Abstract RU 2319745 C1

FIELD: peptides.

SUBSTANCE: invention relates to biologically active peptides possessing antibacterial effect that can be used in biotechnology and medicine. Peptide latarcin shows the following amino acids sequence: H₂N-Gly¹-Phe²-Phe³-Gly⁴-Lys⁵-Met⁶-Lys⁷-Glu⁸-Tyr⁹-Phe¹⁰-Lys¹¹-Lys¹²-X¹³-Gly¹⁴-Ala¹⁵-Ser¹⁶-Phe¹⁷-Lys¹⁸-Arg¹⁹-Arg²⁰-Phe²¹-Ala²²-Asn²³-Leu²⁴-Lys²⁵-Lys²⁶-Arg²⁷-Leu²⁸-NH₂ wherein X represents phenylalanine Phe¹³ or tryptophan Trp¹³residue, and possesses the broad spectrum of antibacterial activity and expressed toxic effect with respect to human promyelocyte leukemia. Using the invention allows expanding assortment of natural peptide antibiotics not containing cysteine residues and possessing high antibacterial activity.

EFFECT: valuable medicinal properties of peptide.

2 tbl, 5 dwg, 8 ex

Similar patents RU2319745C1

Title	Year	Author	Number
LATARCIN PEPTIDES HAVING ANTIBACTERIAL ACTIVITY	2005	Kozlov Sergej Aleksandrovich Vasilevskij Aleksandr Aleksandrovich Feofanov Aleksej Valer'Evich Surovoj Andrej Jur'Evich Arsen'Ev Aleksandr Sergeevich Grishin Evgenij Vasil'Evich	RU2302466C1
LATARCIN PEPTIDES HAVING ANTIBACTERIAL ACTIVITY	2005	Kozlov Sergej Aleksandrovich Vasilevskij Aleksandr Aleksandrovich Feofanov Aleksej Valer'Evich Surovoj Andrej Jur'Evich Arsen'Ev Aleksandr Sergeevich Grishin Evgenij Vasil'Evich	RU2302467C1
LATARCIN PEPTIDE WITH ANTI-MICROBIAL ACTIVITY	2006	Kozlov Sergej Aleksandrovich Vasilevskij Aleksandr Aleksandrovich Vorontsova Ol'Ga Valentinovna Poljanskij Anton Aleksandrovich Volynskij Pavel Evgen'Evich Feofanov Aleksej Valer'Evich Efremov Roman Gerbertovich Arsen'Ev Aleksandr Sergeevich Grishin Evgenij Vasil'Evich	RU2306148C1
METHOD FOR PREPARING ANTIMICROBIAL PEPTIDES WITH DECREASED HEMOLYTIC ACTIVITY	2006	Poljanskij Anton Aleksandrovich Volynskij Pavel Evgen'Evich Vasilevskij Aleksandr Aleksandrovich Vorontsova Ol'Ga Valentinovna Kozlov Sergej Aleksandrovich Feofanov Aleksej Valer'Evich Arsen'Ev Aleksandr Sergeevich Grishin Evgenij Vasil'Evich Efremov Roman Gerbertovich	RU2316336C1
PEPTIDES EXHIBITING ANTIMICROBIAL ACTIVITY	2005	Kozlov Sergej Aleksandrovich Vasilevskij Aleksandr Aleksandrovich Feofanov Aleksej Valer'Evich Arsen'Ev Aleksandr Sergeevich Grishin Evgenij Vasil'Evich	RU2302425C2
PLASMID VECTOR pET-His8-TrxL-Acip1 STRAIN OF BACTERIA Escherichia coli BL21(DE3)/pET-His8-TrxL-Acip1 FOR EXPRESSION OF ANTIMICROBIAL PEPTIDE ACIPENSINA-1 AND METHOD OF PRODUCING SAID PEPTIDE	2015	Balandin Sergej Vladimirovich Panteleev Pavel Valerevich Bolosov Ilja Aleksandrovich Shamova Olga Valerevna Kokrjakov Vladimir Nikolaevich Ovchinnikova Tatjana Vladimirovna	RU2580031C2
pET-mChBac75Na PLASMID VECTOR, ESCHRICHIA COLI BL21(DE3/ pET-mChBac75Na BACTERIA STRAINS FOR CHBAC7NA MINIBACTENECIN ANTIMICROBIAL PEPTIDE EXPRESSION AND METHODS FOR PRODUCTION OF THESE PEPTIDES	2016	Balandin Sergej Vladimirovich Bolosov Ilya Aleksandrovich Panteleev Pavel Valerevich Kokryakov Vladimir Nikolaevich Shamova Olga Valerevna Ovchinnikova Tatyana Vladimirovna	RU2618850C2
PEPTIDE EXHIBITING ANTIBACTERIAL AND ANTITUMOUR PROPERTIES	2019	Panteleev Pavel Valerevich Emelyanova Anna Andreevna Bolosov Ilya Aleksandrovich Balandin Sergej Vladimirovich Shamova Olga Valerevna Kokryakov Vladimir Nikolaevich Ovchinnikova Tatyana Vladimirovna	RU2702661C1
CATIONIC PEPTIDE EXHIBITING ANTIBACTERIAL PROPERTIES	2021	Panteleev Pavel Valerevich Bolosov Ilia Aleksandrovich Ovchinnikova Tatiana Vladimirovna	RU2778856C1
HEMIN DERIVATIVES, HAVING ANTIMICROBIAL ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, SYNTHESIS METHOD, PHARMACEUTICAL COMPOSITION AND USE	2009	Nebol'Sin Vladimir Evgen'Evich Zheltukhina Galina Aleksandrovna Okorochenkov Sergej Aleksandrovich	RU2415868C1

RU 2 319 745 C1

Authors

Kozlov Sergej Aleksandrovich

Vasilevskij Aleksandr Aleksandrovich

Samsonova Ol'Ga Vjacheslavovna

Poljanskij Anton Aleksandrovich

Volynskij Pavel Evgen'Evich

Feofanov Aleksej Valer'Evich

Efremov Roman Gerbertovich

Arsen'Ev Aleksandr Sergeevich

Grishin Evgenij Vasil'Evich

Dates

2008-03-20—Published

2006-09-06—Filed