FIELD: biochemistry, biotechnology, medicine, in particular bioactive peptides.
SUBSTANCE: latarcins 3a and 3b are obtained from poison of spider Lachesana tarabaevi. Said latarcins comprise of 24 amino acid residues, represent linear peptized and have no cysteine residues. Latarcins obtained by chemical synthesis exhibit biological properties being identical to natural ones. Latarcins have antibacterial properties in relates to gram-positive and gram-negative bacteria and yeast fungi. Latarcin peptide has amino acid sequence of H2N-Ser1-Trp2-X3-Ser4-Met5-Ala6-Lys7-Lys8-Leu9-Lys10-Glu11-Tyr12-Met13-Glu14-Lys15-Leu16-Lys17-Gln18-Arg19-Ala20-NH2, wherein X - lysine Lys3 residue (latarcin 3a, LtAMP-3a) or alanine Ala3 residue (latarcin 3b, LtAMP-3b). Latarcins have high antibacterial activity, cytotoxicity in relates to certain cells and are useful in production of pharmaceutical agents.
EFFECT: latarcin peptides having increased antibacterial activity.
6 dwg, 3 tbl, 8 ex
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