FIELD: biochemistry, biotechnology, medicine, in particular bioactive peptides.
SUBSTANCE: latarcins are obtained from poison of spider Lachesana tarabaevi. Latarcins obtained by chemical synthesis exhibit biological properties being identical to natural ones. Said latarcins comprise of 24 amino acid residues, represent linear peptized and have no cysteine residues. Latarcins have antibacterial properties in relates to gram-positive and gram-negative bacteria and yeast fungi. Latarcin peptide has amino acid sequence of H2N-X1 1-Leu1-Lys3-Asp4-Lys5-X2 6-Lys7-Ser8-Met9-Gly10-Glu11-Lys12-Leu13-Lys14-Gln15-Tyr16-Ile17-Gln18-Thr19-Trp20-Lys21-Ala22-Lys23-Phe24-NH2, wherein X1 is glycine Gly1 or serine Ser1 residue; X2 is phenylalanine Phe6 or valine Val16 residue. Latarcins have high antibacterial activity, cytotoxicity in relates to certain cells and are useful in production of pharmaceutical agents.
EFFECT: latarcin peptides having increased antibacterial activity.
5 dwg, 3 tbl, 8 ex
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