LATARCIN PEPTIDE WITH ANTI-MICROBIAL ACTIVITY Russian patent published in 2007 - IPC A61K38/17 A61P31/04 A61P31/10 

FIELD: chemical-and-pharmaceutical industry, biotechnology, medicine, in particular biologically active peptides with anti-microbial action.

SUBSTANCE: invention relates to peptides of general formula 1 (X₁-Lys-Leu-X₂-X₃-X₄-X₅-X₆-Arg-Lys-Ala-Ile-Ser-Tyr-Ala-Val-Lys-Ala-X₂ (1) obtained by modification of starting structure of latarcin peptide, wherein X₁ is absent or is glycine residue (Gly), or Phe-Gly dipeptide, or Leu-Phe-Gly tripeptide, or Gly-Leu-Phe-Gly tetrapeptide; X₂ is glutamine residue (Gln) or isoleucyne residue (Ile); X₃ is arginine residue (Arg) or lysine residue (Lys); X₄ is arginine residue (Arg) or lysine (Lys) residue; X₅ is lysine residue (Lys) or phenylalanine residue (Phe); X₆ is glycine residue (Gly) or leucine residue (Leu); X₇ is absent or is arginine residue (Arg), or Arg-Gly dipeptide, or Arg-Gly-Lys tripeptide, or Arg-Gly-Lys-His tetrapeptide, or Arg-Gly-Lys-Asn tetrapeptide.

EFFECT: new peptide with anti-microbial activity.

7 ex, 4 tbl, 3 dwg