METHOD FOR DETERMINING FUNCTIONAL STATE OF LIVER BY MEANS OF LABELED COMPOUNDS Russian patent published in 2008 - IPC A61B5/1495 A61B6/00 

FIELD: medicine.

SUBSTANCE: method involves carrying out one stage (single syringe) intravenous injection of human blood serum albumin mixed with colloid solution labeled with radioactive markers different in radiation power, into vascular bed, recording and plotting albumin and colloid radioactivity change plots by determining blood, organs and tissues radioactivity recorded in the vicinity of heart, abdominal aorta, liver and spleen during vascular phase. Then, preparation activity changes are recorded in blood, liver and spleen during time period enough for plots to form plateau, zones of interest are selected and activity/time plots are built above cardiac zone (A), above liver zone (B), above spleen zone (C) and above abdominal aorta region (D). Measurement points are selected on the boundary between arterial and portal components of hepatic blood circulation. Point 1 (N1) is placed on curve B which is determined from accumulation peak of curve D above abdominal aorta region between arterial and portal components of hepatic blood circulation. Point 2 (N2) is placed on curve B, which is determined from accumulation peak above spleen as curve C. Point 3 (N3) is determined as vascular phase end when carrying out albumin test at the moment of exit to plateau. Point 4 (N4) is determined at the examination end when all curves come to the plateau. Hepatic blood circulation parameters are determined from albumin activity change data with following relative quantitative blood circulation parameters hepatic P being calculated as arterial blood contribution P_A, portal blood circulation contribution P_p%, portal blood circulation drop degree K%, splenic component P_S%, intestinal component P_I%. The, functional reticuloendothelial hepatic system parameters are determined from colloid activity change data. To determine reticuloendothelial system cells injury degree of curve B, the curve B is subtracted by albumin. Functional value of reticuloendothelial system cells is determined as where is the area under the curve B. Architectonic change index is calculated in liver sectors (I-IV) and spleen sector IL so that if P_A = 25-40%, P_c=20-35%, K=80-100%, A=600-800, IH_1-4=0.09-0.11, IL=0.02-0.04, then hepatosis is to be diagnosed. If P_A = 40-60%, P_c=25-40%, K=50-80%, A=700-900, IH_1-4=0.05-0.08, IL=0.06-0.09, then hepatic cirrhosis is to be diagnosed at compensation stage. If P_A = 60-80%, P_c=40-80%, K=15-50%, A=300-600, IH_1-4=0.03-0.05, IL=0.08-0.11, then decompensed hepatic cirrhosis is to be diagnosed.

EFFECT: high accuracy in determining functional liver condition.

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