LYPOTEICHOIC ACID FROM LACTIC ACID BACTERIA AND USES THEREOF IN MODULATION OF IMMUNE REACTIONS MEDIATED BY GRAM-NEGATIVE BACTERIA AND POTENTIAL PATHOGENIC GRAM-POSITIVE BACTERIA Russian patent published in 2008 - IPC A61K35/74 A61P37/02 A23K1/16 

Abstract RU 2320356 C2

FIELD: medicine.

SUBSTANCE: invention relates to composition for inhibition or prevention of inflammatory processes associated with bacterium-mediated diseases or LTA/LPS-mediated disturbances in gastrointestinal tract in human or animal. Claimed composition contains as active ingredient lypoteichoic acid from lactic acid bacteria belonging to genus Lactobacillus wherein lypoteichoic acid was selected on the base of its capability of binding to CD 14 and disability of inducing the release of anti-inflammatory cytokines such as IL-8 or TNF-α from enteric epithelial cells. Disclosed is application of at least one lypoteichoic acid from lactic acid bacteria belonging to genus Lactobacillus, and/or lactic acid bacterium producing the same, and/or supernatant of its culture for composition production useful in inhibition or prevention of inflammatory processes associated with bacterium-mediated diseases or LTA/LPS-mediated disturbances in gastrointestinal tract, bones, skin, eyes, ears, lungs, and oral cavity in human or animal.

EFFECT: new agent for prevention or inhibition of inflammatory processes.

8 cl, 2 ex, 8 dwg

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RU 2 320 356 C2

Authors

Vidal' Karin

Donne-Jug Anna

Granato Dominik-Ann

Kortezi-Telaz Iren

Dates

2008-03-27Published

2002-04-23Filed