NOVEL ARYLALKYLINDOLES SHOWING AFFINITY TO SEROTONIN RECEPTOR AND USEFUL AS DRUGS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 2008 - IPC C07D487/04 A61K31/40 A01P5/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes compound of the general formula (I): wherein R₀ represents hydrogen atom; R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈, R₉, R₁₀, R₁₁ and R₁₂ can be similar or different and each represents independently hydrogen atom, halogen atom, perhalogenalkyl, substituted or unsubstituted groups, such as linear or branched (C₁-C₁₂)-alkyl, (C₃-C₇)-cyclaoalkyl, (C₁-C₁₂)-alkoxy, cyclo-(C₃-C₇)-alkoxy group, hydroxyalkyl; R₁₃ and R₁₄ can be similar or different and each represents independently hydrogen atom, substituted or unsubstituted groups, such as linear or branched (C₁-C₄)-alkyl, (C₃-C₇)-cycloalkyl, optionally, R₁₃ and R₁₄ in common with nitrogen atom can form 5-6-membered heterocyclic ring wherein heterocycle can be substituted also, and it can comprise one, two or three double bonds or "additional heteroatoms" chosen from nitrogen atom (N); "n" means a whole number in the range 1-6, and pharmaceutical compositions based on its. Indicated compounds are ligands of 5-HT (serotonin) and can be used in treatment in cases if modulation of activity of 5-HT and melatonin is desirable.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.

21 cl, 31 ex