NOVEL TETRACYCLIC ARYLSULFONYL-INDOLES WITH AFFINITY FOR SEROTONIN RECEPTORS, ACCETABLE AS MEDICATIONS, METHOD OF THEIR OBTAINING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2008 - IPC C07D513/04 A61K31/429 A61P25/00 

Abstract RU 2340619 C2

FIELD: chemistry.

SUBSTANCE: in general formula (I) , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 can be similar or different and represent, each independently, hydrogen, halogen, hydroxyl, unsubstituted (C1-C6)alkyl, (C1-C6)alkoxy, or neighbouring groups R2 and R3 together with carbon atoms to which they are bound, can form benzol ring; R13 and R14 can be similar or different and represent each independently, hydrogen, unsubstituted (C1-C6)alkyl, optionally, R13 and R14 together with nitrogen atom can form 5-, 6-member heterocyclic ring, where heterocycle also can be substituted (C1-C6)alkyl, and it can have "additional heteroatoms", selected from O, N; "n" is an integer in interval from 1 to 4, and carbon chain, to which it relates is linear.

EFFECT: compound possess the characteristic of activity modulators 5-HT and can be applied for treatment of such diseases as anxiety, depression, convulsive syndromes, migraine.

15 cl, 67 ex

Similar patents RU2340619C2

Title Year Author Number
NOVEL ARYLALKYLINDOLES SHOWING AFFINITY TO SEROTONIN RECEPTOR AND USEFUL AS DRUGS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF 2003
  • Dzhasti Venkatesvarlu
  • Ramakrishna Venkata Sat'Ja Nirogi
  • Kambkhampati Rama Sastri
  • Battula Srinivasa Reddi
  • Rao Venkata Sat'Ja Veerabkhadra Vadlamudi
RU2320663C2
NEW TETRACYCLIC ARYLCARBONYLINDOLS WITH AFFINITY TO SEROTONINE RECEPTORS APPLICABLE AS PHARMACEUTICALS, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS ON THEIR BASE 2003
  • Dzhasti Venkatesvarlu
  • Ramakrishna Venkata Sat'Ja Nirogi
  • Kambkhampati Rama Sastri
  • Battula Srinivasa Reddi
  • Rao Venkata Sat'Ja Veerabkhadra Vadlamudi
RU2325392C2
NEW 3-INDOLE SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF APPLICATION 2016
  • Ninkovic Sacha
  • Crosignani Stefano
  • Scales Stephanie Anne
  • Mcalpine Indrawan James
  • Collins Michael Raymond
  • Maderna Andreas
  • Wythes Martin
RU2672252C1
DERIVATIVES OF SUBSTITUTED DIHYDROPYRANOINDOLE-3,4-DIONE AS INHIBITORS OF PLASMINOGENE ACTIVATOR INHIBITOR-1 (PAI-1) 2003
  • Ilokdakh Khassan Makhmud
  • Li Dehvid Zenan
RU2337910C2
URAT1 INHIBITORS 2015
  • Anzai, Naohiko
  • Endou, Hitoshi
  • Hirano Masuharu
  • Saito, Daisuke
  • Tanaka, Hiroto
  • Kobayashi, Kunio
  • Endo, Tsuyoshi
RU2721844C2
ISOXAZOLE DERIVATIVES, PROCESS FOR PREPARING THEREOF, HERBICIDAL COMPOSITION, AND METHOD OF CONTROLLING WEEDS 1994
  • Nejl Gich
  • Dehvid Vil'Jam Khaukins
  • Kristofer Dzh.Piarson
  • Filip Khenri G.Smit
  • Nikolas Vajt
RU2126394C1
DERIVATIVES OF THIOPHENE 2003
  • Ehndrjus Klarens U. Tretij
  • Chijung M'Jui
  • Dehjvis-Uord Ronda Dzh.
  • Druri Dejvid Kharol'D
  • Ehmmitt Kajl Allen
  • Khabbard Robert Dejl
  • Kunts Kevin U.
  • Linn Dzhejms Ehndrju
  • Muk Robert Ehntoni
  • Smit Gehri Kejt
  • Vil Dzhejms Marvin
RU2296758C2
SUBSTITUTED COMPOUNDS OF PYRIDINE AZOLOPYRIMIDINE-5-(6H)-ONE 2013
  • Allan Emi
  • Branstetter Brajan
  • Dik Brajan
  • Vajnkhaus Majkl I.
  • Gomez Loran
  • Merron Temi Dzho
  • Piters Marko
RU2653054C2
INDOL(SULFONIL)-N-HYDROXYBENZAMIDE DERIVATIVES AS SELECTIVE HDAC INHIBITORS 2018
  • Srivari, Chandrasekhar
  • Mainkar, Prathama Satyendra
  • Reddy, Chada Raji
  • Kotamraju, Srigiridhar
  • Togapur, Pavan Kumar
  • Muppidi, Subbarao Mohan Venkata
  • Sharma, Somesh
  • Jha, Ashok Kumar
  • Arumugam, Prem Kumar
RU2748835C1
BENZOTHIOPHENES AND RELATED COMPOUNDS AS STING AGONISTS 2019
  • Altman, Majkl, D.
  • Kesh, Brendon, D.
  • Childers, Mettyu Llojd
  • Kamming, Dzhared, N.
  • Demong, Duejn, E.
  • Khejdl, Endryu Mark
  • Khenderson, Timoti, Dzh.
  • Dzhuvell, Dzhejms, P.
  • Larsen, Mettyu, A.
  • Lim, Dzhongvon
  • Lu, Min
  • Otte, Rajan, D.
  • Trotter, Bendzhamin Uesli
RU2806274C2

RU 2 340 619 C2

Authors

Dzhasti Venkatesvarlu

Ramakrishna Venkata Sat'Ja Nirogi

Kambkhampati Rama Sastri

Battula Srinivasa Reddi

Veeraraeddi Arava

Rao Venkata Sat'Ja Veerabkhadra Vadlamudi

Dates

2008-12-10Published

2003-06-19Filed