FIELD: molecular biology, bioorganic chemistry.
SUBSTANCE: method for preparing DNA-chip involves modifying a polymer surface comprising electrophilic groups with compound of the formula: H2N-X-Si(OR)3 wherein X means propyl; R means ethyl in gaseous phase, and with a solution of compound of the formula: Y-X-Si(OR)3 wherein Y means a functional group; X means propyl; R means ethyl or methyl. Then oligonucleotide is immobilized on the modified surface of a polymer by the covalent route. Use of the invention provides decreasing the cost and enhancing effectiveness of modification of backing in production of DNA-chips.
EFFECT: improved preparing method.
11 cl, 10 dwg, 2 tbl, 14 ex
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