FIELD: biotechnology, genetic engineering. SUBSTANCE: recombinant DNA pCVA is constructed designed for effective expression of stable and biologically active ribosime in eucaryotic cells and consisting of vector plasmid pUC 1813 and MaeI-CfrI-fragment (size is 180 nucleotide pairs) from the avian adenovirus CELO genome that contains gene of virus-associated RNA. EFFECT: improved method of recombinant DNA construction, enhanced effectiveness of expression. 1 dwg
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