METHOD FOR EVALUATING ENDOTHELIAL FUNCTION IN A YOUNG PATIENT Russian patent published in 2008 - IPC G01N33/68 G01N33/52 A61B8/00 

FIELD: medicine, cardiology, neurology.

SUBSTANCE: for evaluating endothelial function in young patients it is necessary to detect the following parameters: the concentration of endothelin-1 in blood plasma (C_Et-1) during morning hours; total concentration of basic level of stable metabolites of nitrogen oxide - nitrites and nitrates, detected in blood plasma during morning hours (C_NO); the ratio of the above-mentioned concentrations; the value of endothelium-dependent vasodilation (EDVD) obtained due to applying ultrasound high-frequency impact at frequencies ranged 7 MHz up to 12 MHz. One should conclude upon normal endothelial function in a young patient at the values of the above-mentioned parameters being within: C_Et-1=0.05-0.34 fM/ml, C_NO=17-25 mcM/dl, C_Et-1/C_NO≤0.02, EDVD=(d₁-d)/d=3-16%, where d₁ - the diameter of brachial artery in case of reactive hyperemia, d - the diameter of brachial artery at rest.

EFFECT: higher accuracy of evaluation.

7 ex, 4 tbl