NOVEL DERIVATIVES OF CYCLOALKANEDIONE, METHOD FOR THEIR PREPARING AND THEIR USING IN PHARMACEUTICS Russian patent published in 2008 - IPC C07D487/04 C07D513/04 C07D277/34 A61K31/4188 A61K31/381 A61P9/10 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of the general formula (I): wherein R₁ is chosen from group consisting of hydrogen atom (H), -(CH₂)₃-, -(CH₂)₄-, -CH₂-S-CH₂-, -S-CH₂-CH₂-; R₂ is chosen from group consisting of nitrogen (N), sulfur (S) atom; n = 0 or 1; Z is chosen from group consisting of (C₂-C₁₀)-alkyl; R₃ is chosen from group consisting of H; m = 0-2; R₄ is chosen from group consisting of oxygen atom (O), -CH₂-; R₅ is chosen from group consisting of the following groups:

wherein R₆ is chosen from group consisting of H, alkyl-(C₁-C₅)-alkoxyl; W is chosen from group consisting of -NH wherein each "alkyl" can be linear or branched and can be also cyclic or linear, or branched and comprises such cyclic residues, and each "aryl" comprises monocyclic aromatic group comprising 5-12 carbon atoms bound with one or some heteroatoms chosen from N, O or S atoms, and to their salts and solvates. Also, invention relates to a pharmaceutical composition, to a method for their synthesis and using compounds by claims 1-6. Invention provides synthesis of novel active compounds and pharmaceutical compositions based on thereof that possess affinity to serotonin receptors of subtype 5-HT_1A.

EFFECT: valuable medicinal properties of compounds, improved method of synthesis.

10 cl, 4 tbl, 26 ex