NOVEL DERIVATIVES OF BENZIMIDAZOLE, METHODS FOR THEIR PREPARING, THEIR USING AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF Russian patent published in 2008 - IPC C07D235/12 C07D403/06 C07D401/06 C07D405/14 C07D401/14 C07D409/14 C07D413/14 C07D413/06 A61K31/4184 A61P35/00 A61P25/28 A61P25/16

Abstract RU 2323211 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to therapeutic agents showing effectiveness in treatment of pain, cancer, cerebrospinal sclerosis, Parkinson's disease, Huntington's chorea and/or Alzheimer's disease. Invention describes compound of the formula (I): or its pharmaceutically acceptable salts wherein R^F1 and R^F2 represent independently electron-acceptor groups; Z is chosen from O=; R¹ is chosen from (C₁-C₁₀)-alkyl, heterocyclyl-(C₁-C₆)-alkyl, substituted heterocyclyl-(C₁-C₆)-alkyl; R² is chosen from (C₁-C₆)-alkyl; X represents bivalent (C₁-C₁₀)-group that separates groups added to it by one or two atoms; Ar represents bivalent (C₄-C₁₂)-aromatic group, and Y is chosen from =CH=. Also, invention describes fields wherein compounds of the formula (I) are used, a pharmaceutical composition based on thereof, and methods for their synthesis. Invention provides synthesis of novel compounds possessing useful biological properties.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

17 cl, 2 tbl, 35 ex

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RU 2 323 211 C2

Authors

Pazhe Daniehl'

Uolpol Kristofer

Jang Kh'Juehj

Dates

2008-04-27—Published

2003-10-15—Filed