BIPHENYLMETHYLTHIAZOLIDINEDIONS AND ANALOGUES AND THEIR USING AS PPAR-GAMMA ACTIVATORS Russian patent published in 2008 - IPC C07D277/34 C07D417/12 C07C233/87 C07C235/78 C07C235/66 A61K31/426 A61K31/427 A61Q5/00 A61Q19/08 A61P17/00 

FIELD: organic chemistry, medicine, pharmacy, cosmetology.

SUBSTANCE: invention relates to novel biphenylmethylthiazolidinedions of the general formula (I): , their salts, and to their optical and geometrical isomers possessing agonistic activity with respect to PPARγ receptors, to pharmaceutical and cosmetic compositions based on thereof, and to their using for preparing composition used in treatment of different cutaneous diseases. In compound of the formula (I) R₁ means radical of the following formula (a): or (b): ; R₂ and R₃ mean hydrogen atom; X means binding groups showing the following structures: -CH₂-N(R₈)-CO-, -N(R₈)-CO-N(R₉)- that can be read from left to right or vice versa; R₄ means phenyl substituted with group R₁₀, pyrrolyl, naphthyl, biphenyl, indenyl, benzothienyl and all these groups can be mono- or di-substituted with group R₁₁ and/or R₁₂, group -(CH₂)_n-(CO)_qR₁₃, adamantyl, cyclopentylethyl, group -(CH₂)_n-O-R₁₃; R₅ means hydroxyl or alkoxyl with 1-19 carbon atoms; R₆ means group -OR₁₄. Values R₈, R₉, R₁₀, R₁₁, R₁₂, R₁₃, n and q are given in the invention claim.

EFFECT: valuable medicinal properties of compounds.

25 cl, 2 dwg, 37 ex