FIELD: organic chemistry, medicine, cosmetics, pharmacy.
SUBSTANCE: invention relates to compounds of the formula (I): 
wherein R1 means radical of the following formulae: (a) 
or (b) 
wherein R2 and R3 are similar or different and mean hydrogen atom, alkyl with 10-12 carbon atoms, aryl, radical -OR7; X means a binding fragment of the following formula: -(CH2)m-(Z)n-(CO)p-(W)q- wherein a binding fragment can be read from the left to the right or inversely; R4 means alkyl with 1-12 carbon atoms, aryl, aralkyl, heteroaryl or 9-fluorenylmethyl; Y means radical -CH2 or sulfur atom; R5 means hydroxyl, alkoxyl with 1-6 carbon atoms, radical -NH-OH or radical -N(R8)(R9); R6 means alkyl with 1-12 carbon atoms, radical -OR10 or radical -(CH2)r-COR11; R7 means hydrogen tom or aralkyl; Z means oxygen atom or radical -NR12; W means oxygen atom, radical -NR13 or radical -CH2; m, n, p and q are similar or different and can mean 0 or 1 under condition that the sum (m + n + p + q) = 2 or above, and when p = 0 then n or q = 0; R8 means hydrogen atom; R9 means hydrogen atom or aryl; r means 0 or 1; R10 means alkyl with 1-12 carbon atoms; R11 means hydroxyl or radical -OR14; R12 means hydrogen atom or alkyl with 1-12 carbon atoms; R13 means hydrogen atom or alkyl with 1-12 carbon atoms; R14 means alkyl with 1-12 carbon atoms; and optical and geometric isomers of abovementioned compounds of the formula (I), and their salts also. These compounds are useful as activating agents of receptors of type PPAR-γ in pharmaceutical compositions designated for using in medicine, in particular, in dermatology, in treatment of cardiovascular diseases and related to immunity of diseases and/or diseases associated with lipid metabolism, and in cosmetic compositions also.
EFFECT: valuable properties of compounds and compositions.
19 cl, 1 tbl, 2 dwg, 37 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BIPHENYLMETHYLTHIAZOLIDINEDIONS AND ANALOGUES AND THEIR USING AS PPAR-GAMMA ACTIVATORS | 2002 |
|
RU2323212C2 |
| PPARγ RECEPTOR MODULATING NOVEL COMPOUNDS AND USE THEREOF IN COSMETIC AND PHARMACEUTICAL COMPOSITIONS | 2004 |
|
RU2401836C2 |
| DERIVATIVES OF FIVE-MEMBERED HETEROCYCLES, THEIR PREPARING AND USING AS MEDICINAL AGENTS | 2002 |
|
RU2288224C2 |
| TETRASUBSTITUTED DERIVATIVES OF IMIDAZOLE, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2174513C2 |
| DERIVATIVES OF FIVE-MEMBER HETEROCYCLES, METHOD OF PRODUCTION AND USE THEREOF AS MEDICINAL AGENTS | 2000 |
|
RU2380362C2 |
| FIVE-MEROUS HETEROCYCLE DERIVATIVES, METHOD FOR PREPARING AND USING THEM AS THERAPEUTIC AGENTS | 2009 |
|
RU2530882C2 |
| DERIVATIVES OF FIVE-MEMBERED HETEROCYCLES, METHOD FOR THEIR PREPARING AND THEIR USING AS MEDICINES | 2000 |
|
RU2271355C2 |
| BENZAMIDE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS OF SAID DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED THERE ON AND APPLICATION THEREOF | 2004 |
|
RU2333198C2 |
| FIVE-MEMBERED HETEROCYCLES WITH BIPHENYLSULFONYL SUBSTITUTION, MEDICINAL AGENT | 1998 |
|
RU2242466C2 |
| PYRIMIDOTRIAZINES, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND USING | 2002 |
|
RU2289583C2 |
