METHOD FOR DIAGNOSIS OF SENSITIZING TO WATER-SOLUBLE INDUSTRIAL ALLERGENS Russian patent published in 2008 - IPC G01N33/52 G01N33/543 

FIELD: medicine, immunology, allergology.

SUBSTANCE: method involves determination of the level of allergen-specific antibodies - immunoglobulins of subclasses IgG1 and IgG4 in serum blood using the specific allergen Coefficient of specific allergizing (SAC) is calculated by the following formula:

SAC = (parent (IgG4 + IgG1) - control sample (G4C + G1C))/(parent (IgG4 + IgG1) - sample with allergen (G4A + G1A)) wherein IgG1 and IgG4 are the level of the parent indices of corresponding subclasses of immunoglobulins G; G1A and G4A are the levels of corresponding subclasses of immunoglobulins G in addition of allergen; GrC + G1C are the level of corresponding subclasses of immunoglobulins G without addition of allergen. The presence of IgG-dependent sensitizing to a specific industrial allergen is provide at SAC value less 2.5. Method provides enhancing diagnosis for the presence of sensitizing to allergen and to reduce time of analysis. Invention can be used for diagnosis of professional diseases.

EFFECT: improved method of diagnosis.

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