ASAINDOLES Russian patent published in 2008 - IPC C07D471/04 C07D487/04 A61K31/437 A61K31/4985 A61P29/00 A61P11/00 A61P9/00 

FIELD: medicine; pharmacology.

SUBSTANCE: invention refers to pharmaceutical formulation inhibiting protein kinase, containing inhibiting selective kinase compound amount of general formula (I): , where: R means aryl or indolyl, and the latter is optionally substituted with one or more groups selected from R⁴, -C(=O)-R, -C(=O)-OR⁵, -C(=O)-NY¹Y² and -Z²R; R² means H; R³ means H; R⁴ means C₁-C₆ alkyl, optionally substituted with one substitute -C(=O)-NY¹Y²; R⁵ means H; R⁷ means C₁-C₆ alkyl; R means C₁-C₆ alkyl; X¹ means C-aryl, C-heteroaryl, such as pyridile or isoxasolyl, and the latter is optionally substituted with one or two C₁-C₆ alkyls, C-heterocycloalkyl, such as morpholinile or peperidynil, C-halogen, C-CN, C-OH, C-Z²R, C-C(=O)-OR⁵, C-NY^lY², C-C(=O)-NY¹Y²; Y¹ and Y² means redardless H, aryl, C₃-C₆ cycloaryl, C_1-C₆ alkyl, optionally substituted with one group selected from phenyl, halogen, heterocyclil, such as morpholinile, phurile, hydroxyl, -C(=O)-OR⁵, OR⁷; or group-NY¹Y² can form morpholinile, peperidynil, optionally substituted with one or two substitutes selected from OH, C₁-C₆ alkyl; Z means O; where aryl as group or part of group means optionally substituted with one or two substitutes monocyclic aromatic C₆carbocyclic fragment, where substitute is selected from halogen or C₁-C₆ alkoxy, C(=O)-OR⁵; except compounds: 4-chlorine-2-(4-tert-butylphenyl)-1H-pyrrole[2,3-b]pyridine, 2-(5-methoxy-1 -methyl-1 H-indole-3-il)-4-phenyl-1H- pyrrole[2,3-b]pyridine, 2-(5- methoxy-1 -methyl-1 H-indole-3-il)-1H- pyrrole[2,3-b] pyridine-4-carbonitrile, 4-chlorine-2-(5- methoxy-1 -methyl-1H-indole-3-il)-1H- pyrrole[2,3-b]pyridine, or 2-(5- methoxy-1H-indole-3-il)-1H- pyrrole[2,3-b]pyridine -4- carbonitrile.

EFFECT: application of compound for production of medicinal agent for inflammatory disease.

51 cl, 9 tbl, 148 ex