METHOD OF OBTAINING DERIVATIVES OF HYDROXYALKYL STARCH Russian patent published in 2008 - IPC C08B31/12 A61P7/06 C07K17/02 C07K17/10 

FIELD: chemistry.

SUBSTANCE: method of obtaining a derivative of hydroxyalkyl starch, where the given derivative has a structure, corresponding to formula (I), involves reaction of the hydroxyalkyl starch with formula (I) through its oxidised-reduced end, or a derivative of hydroxyalkyl starch, obtained from reaction of hydroxyalkyl starch of formula (I) through its oxidised-reduced end with compound (D), where compound (D) consists of at least one functional group Z₁, capable of reacting with the oxidised-reduced end of hydroxyalkyl starch, and at least one functional group W, with compound (L), consisting of at least one functional group Z₁, capable of reacting with the indicated hydroxyalkyl starch, or at least one functional group Z₂, capable of reacting with functional group W, contained in the given derivative of hydroxyalkyl starch, and at least one functional group X, capable of reacting with functional group Y in another compound (M), where the given functional group Y is chosen from a group, consisting of an aldehyde group, keto group, hemiacetal group, acetal group and a thio group, where formation of a bond between compound (L) and hydroxyalkyl starch or compound (D) and hydroxyalkyl starch is achieved through reaction of functional group Z₁ with the oxidised-reduced end of hydroxyalkyl starch, and where functional group Z₁ contains an -NH structure.

EFFECT: invention also relates to derivatives of hydroxyalkyl starch, as well as to pharmaceutical compositions, containing derivatives of hydroxyalkyl starch.

54 cl, 26 dwg, 3 tbl