FIELD: medicine. SUBSTANCE: invention relates to biocompatibility of oxygen transfers for administration to patients as an addition or partial substitution of whole blood. Hemoglobin conjugates that can be used as oxygen transfers based on hemoglobin are prepared using providing hemoglobin reaction with polysaccharides with ring opened in oxidation, such as hydroxyethylstarch or dextran and storage the prepared conjugate under conditions that allow to its after conjugation to be transformed into product with lower molecular mass. Then conjugate is subjected for reductive stabilization to form secondary amino-bonds between hemoglobin and polysaccharide and to make the hemoglobin-base composition as an oxygen transfer. Method provides preparing new conjugate polysaccharide-hemoglobin. EFFECT: improved preparing method, valuable medicinal properties of conjugates. 45 cl, 12 dwg, 11 ex
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