DERIVATIVES OF 2-(IMINOMETHYL)AMINOPHENYL, METHODS OF SYNTHESIS, PHARMACEUTICAL COMPOSITION Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, biochemistry, pharmacy. SUBSTANCE: invention relates to 2-(iminomethyl)amino-phenyl derivatives of the general formula (I) where A is aromatic residue of the formula (Ia) ; R₁ and R₂ mean independently hydrogen, halogen atom, hydroxyl-group, linear or branched C₁-C₆-alkyl, linear or branched C₁-C₆-alkoxyl; R₃ is hydrogen atom, linear or branched C₁-C₆- alkyl or -COR₄ where R₄ is -C₁-C₆-alkyl or residue of the formula (Ib); B means linear or branched -alkyl or 5-membered heterocycle including 1-4 heteroatoms taken among O, S, N and, in part: thiophene, furan, pyrrol or thiazole where carbon atoms are unsubstituted or substituted with one or some groups taken among linear or branched C₁-C₆-alkyl, C₁-C₆-alkoxyl or halogen atom; X means -CO-C₁-C₆-X'-, -NH-CO-X'-, CH=, -CO- or linkage being X' means N(R₃) where n = 0-6; Y means -Y'-, -Y'-NH-CO-, -CO-Y'-, -Y'-CO-, -(CH₂)_n-Y'-, -Y-N(R₃)-, Y'-CH₂-N(R₃)-CO-, -Y'-O-, -Y'-O-Y' or linkage being Y' means -(CH₂)_n- where n = 0-6 ; Het means pyrrol, pyrrolidine, furan, thiophene, imidazole, imidazoline, oxazole, isoxazole, oxazoline, isoxazoline, thiazole, thiazoline, thiazolidine, thiazolidinone, azethidine, piperidine, imidazoli- dinedione, imidazolidinone. Compounds of the formula (I) show simultaneous activity as inhibitors of NO-synthase activity and lipid peroxidation. EFFECT: improved method of synthesis, valuable biochemical properties of compounds. 14 cl