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RU

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2 329 807

(13)

C2

(51)

IPC

A61K31/565(2006-01-01)

A61K36/8945(2006-01-01)

A61P5/30(2006-01-01)

(21) (22)

Application

2006125310/14, 2006-07-14

(24)

Start date

2006-07-14

(22)

Actual filing date

2006-07-14

(45)

Published

2008-07-27

(72)

Inventor

Korokin Mikhail ViktorovichPokrovskij Mikhail VladimirovichNosov Aleksandr MikhajlovichKochkarov Vladimir IskhakovichKorokina Lilija ViktorovnaPokrovskaja Tat'Jana Grigor'EvnaGladchenko Mikhail PetrovichArtjushkova Elena BorisovnaKorneev Marat MauludovichDudka Viktor TarasovichIvanov Aleksandr ViktorovichFajtel'Son Aleksandr Vladimirovich

(73)

Holder

Korokin Mikhail ViktorovichNosov Aleksandr Mikhajlovich

METHOD OF CORRECTION OF HYPOESTROGEN-INDUCED ENDOTHELIAL DYSFUNCTION WITH FUROSTANOL GLYCOSIDES OF CELL CULTURE OF Dioscorea deltoidea Russian patent published in 2008 - IPC A61K31/565 A61K36/8945 A61P5/30 

Abstract RU 2329807 C2

FIELD: medicine.

SUBSTANCE: invention refers to medicine, specifically to experimental cardiology and endocrinlogy, and concerns correction of hypoestrogen-induced endothelial dysfunction. For this purpose, rat females of Wistar line is daily intraperitoneally introduced with furostanol glycosides of cell culture Dioscorea deltoidea within 6 weeks after ovariectomy in dosage 1 mg/kg once a day. Method provides effective correction of endothelial dysfunction without any by-effects due to estrogen-like activity of furostanol glycosides.

EFFECT: development of effective method of correction of endothelial dysfunction without any by-effects.

1 ex, 2 tbl

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RU 2 329 807 C2

Authors

Korokin Mikhail Viktorovich

Pokrovskij Mikhail Vladimirovich

Nosov Aleksandr Mikhajlovich

Kochkarov Vladimir Iskhakovich

Korokina Lilija Viktorovna

Pokrovskaja Tat'Jana Grigor'Evna

Gladchenko Mikhail Petrovich

Artjushkova Elena Borisovna

Korneev Marat Mauludovich

Dudka Viktor Tarasovich

Ivanov Aleksandr Viktorovich

Fajtel'Son Aleksandr Vladimirovich

Dates

2008-07-27—Published

2006-07-14—Filed

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