FIELD: medicine.
SUBSTANCE: endothelial dysfunction is stimulated in laboratory animal by intraperitoneal introduction of N-nitro-L-arginine methyl ether in dosage 25 mg/kg daily for seven days. The dysfunction severity is estimated by a relation of endothelium-independent and endothelium-dependent vasodilatation indices. Endothelial dysfunction is corrected by subcutaneous introduction of recombinant erythropoietin in dosage 50 IU/kg for the first, third and fifth days of experiment in the morning.
EFFECT: method provides correcting endothelial dysfunction in L-NAME induced nitrogen oxide deficiency.
1 ex, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION BY COMBINATION OF TRIMETAZIDINE AND L-ARGININE IN L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY | 2009 |
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RU2421822C2 |
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| METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF LOZARTAN AND RAZVERATROL IN CASES OF LONAME-INDUCED NITROGEN MONOXIDE DEFICIENCY | 2005 |
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| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH PREPARATION PHOSPHOGLIV LYOPHILIZATE IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2008 |
|
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| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF LOSARTAN AND L-ARGININE IN L-NAME-INDUCED NITROGEN DEFICIT | 2005 |
|
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| METHOD OF ACETYLSALICYLIC ACID BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
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| METHOD OF CLOPIDOGREL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
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|
RU2306953C1 |
| METHOD OF LAMOTRIGINE CORRECTION OF ENDOTHELIAL DYSFUNCTION ASSOCIATED WITH L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2008 |
|
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RU2364393C1 |
