METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF LOZARTAN AND RAZVERATROL IN CASES OF LONAME-INDUCED NITROGEN MONOXIDE DEFICIENCY Russian patent published in 2007 - IPC A61K31/05 A61K31/4178 A61P9/10 

Abstract RU 2306924 C1

FIELD: experimental cardiopharmacology.

SUBSTANCE: in an experiment, endothelial dysfunction is simulated by daily, over a 7-day period, intraperitoneal introduction of L-arginine methyl ether to rats in dose of 25 mg/kg. Then, on the 7th day since the beginning of experiment, lozartan in dose 6 mg/kg is introduced intragastrically and razveratrol in dose 2 mg/kg intraperitoneally once a day.

EFFECT: increased correction efficiency under specific experiment conditions.

2 tbl

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RU 2 306 924 C1

Authors

Pokrovskij Mikhail Vladimirovich

Kochkarov Vladimir Iskhakovich

Pokrovskaja Tat'Jana Grigor'Evna

Gladchenko Mikhail Petrovich

Artjushkova Elena Borisovna

Novikov Oleg Olegovich

Afanas'Ev Jurij Ivanovich

Zhiljakova Elena Teodorovna

Pashin Evgenij Nikolaevich

Litvinov Sergej Alekseevich

Danilenko Ljudmila Mikhajlovna

Rykova Nina Ivanovna

Korokin Mikhail Viktorovich

Korokina Lilija Viktorovna

Gumanova Nadezhda Georgievna

Dates

2007-09-27Published

2005-12-28Filed