METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION BY COMBINATION OF ENALAPRIL AND RESVERATROL IN L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE Russian patent published in 2007 - IPC A61K31/401 A61K31/01 A61P9/12 G09B23/28 

FIELD: medicine, experimental cardiopharmacology.

SUBSTANCE: method involves modeling the endothelial dysfunction by every day intraperitoneal administration of L-nitroarginine methyl ester in rats (Wistar strain) in the dose 25 mg/kg for 7 days. On background of dysfunction modeling its correction is carried out by simultaneous intragastric administration of enalapril in the dose 0.5 mg/kg and by intraperitoneal administration of resveratrol in a single dose 2 mg/kg per 24 h. Degree of dysfunction development and activation of its correction are evaluated by the ratio endothelium-independent and endothelium-dependent vasodilation. Method provides possibility for study of endothelium-protective effects of resveratrol and activation of endothelial NO-synthase at stage of modeling endothelial dysfunction and their evaluation by the above given ratio endothelium-independent and endothelium-dependent vasodilation. Invention can be used in correction of endothelial dysfunction.

EFFECT: improved method of correction.

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