FIELD: chemistry.
SUBSTANCE: invention relates to the method of obtaining the compound of the formula (IV) , which includes the epoxidation of the compound of the formula (I) the agent of oxidation in the presence of optically active compound with the formation of the compound of formula (II) , adding the gent to break the reaction, in order to extinguish any surplus oxidising agent present, where the agents for breaking the reaction are tri(C1-C6)alkylphosphite; without the isolation of the compound of the formula (II), the interaction of the reaction mixture, which includes the compound of the formula (III) in the presence of the base and the cleaning of the compound of the formula (IV) by crystallisation. The invention also relates to the method of obtaining the compound of the formula (IX) , which includes the reaction of the compound of formula (IV) with a silylation agent with the formation of a compound of the formula (V) ; the reaction of the compound of formula (V) with the silylation agent of the formula R'SO2X, where R' represents the remainder of sulfonic acid (C1-C6) alkyl and the X represents the detached group, with the obtaining of the compound of formula (VII) ; the substitution of the sulphonyloxy-group with the obtaining of the compound of the formula (VIII) and reaction of the compound of the formula (VIII) with ammonia or a compound of ammonia obtaining a compound of the formula (IX). The invention also relates to the intermediate compounds (V) and (VI) The compound of the formula (IX) can be used for obtaining a biologically active material - (S, S) - reboxetin. . In the given structural formulas pit independently are equal to 0 or a whole number from 1 up to 5; each of the groups R and R1, which can be identical or different, represents C1-C6 alkoxy or C1-C6 alkyl; P represents the protective group; R' represents the remainder of sulfonic acid (C1-C6) alkyl.
EFFECT: obtaining aril ethers.
14 cl, 5 ex
Authors
Dates
2008-07-27—Published
2005-02-08—Filed