METHOD OF CHLORINE e6 PRODUCTION Russian patent published in 2008 - IPC C07D487/22 

FIELD: medicine; pharmacology.

SUBSTANCE: invention refers to pharmacology, namely to production of biologically active compounds, specifically to improved method of chlorine e6 production applied for production of photosensitisers for photodynamic cancer therapy. Method is performed by processing sulphuric acid concentrated spirulina methanolic suspensions followed by filtration, dilution with water, alkali neutralisation by, filtration of settled deposition through celite layer followed with washing in hot water and petroleum-ether, elution with acetone celite, silica gel based chromatography, recrystallisation of mixed chloride methylene- methanol, release of produced alkylpheophorbide and its dilution with acetone, alkali processing, hydrochloric acid neutralisation, a filtration through celite layer, washing in water, aqueous ammonia, lyophilisation, dilution with aqueous alkali, filtration through sephadex layer, neutralisation, centrifugation and lyophilisation.

EFFECT: production of pure product with reagents taken in small amounts.

1 cl, 6 ex