PHOTOSENSITISER AND PREPARATION METHOD THEREOF Russian patent published in 2011 - IPC C07D487/22 A61P35/00 A61K31/409 

FIELD: chemistry.

SUBSTANCE: method of preparing photosensitiser involves treatment of a suspension of lyophilically dried spirulina, for example, in methanol or a absolute alcohol until alkyl pheophorbide is obtained and with reaction of the latter with ethylenediamine for example, preferably in an organic solvent, extraction of the corresponding ether of a monoamide of chlorine e 6, its dissolution in alcohol and adding, for example, adipic acid in molar ratio 2:1. Apyrogenic water is added to the photosensitiser of structural formula (1), such that content of chlorine salts is equal to 30-40 mg per 10 ml of the alcohol-water mixture (1:1).

EFFECT: replacing the negative charge on the periphery of the chlorine macrocycle with a positive charge by introducing into the peripheral substitute amine groups to obtain cation-charged chlorines in order to change distribution of the photosensitiser in the body in order to increase affinity to tumours, possibility of controlling distribution owing to combination of different alkyls and different organic acids with different basicity in the structural formula through a novel drug formulation, having good therapeutic properties for treating cancer and other diseases through photodynamic therapy methods for cancer and other neoplastic diseases of different origins compared to existing medicinal agents containing chlorine e 6.

5 cl, 6 ex, 9 dwg